胡国良(1967.01),男,博士,教授(二级),博士研究生导师。伟德国际BETVlCTOR动物医学一级博士点负责人,动物医学国家一流专业负责人,动物医学“十二五”重点建设学科专业负责人,江西省研究生“金牌导师”,入选江西省中青年学科带头人,江西省“千人计划”科技创新高端人才项目,江西省新世纪百千万人才工程人选。现任伟德国际BETVlCTOR南昌商学院经理,教育部高等学校动物医学类教育指导委员会委员,江西省畜禽疾病诊断和防控重点实验室主任,江西省政协常委,民进江西省第九届委员会副主委(副厅级),省政协农业和农村委员会副主任。从事临床兽医学的教学、科研和技术推广工作,有过硬的兽医临床实践能力,主攻方向为动物疾病诊断、监测与防控,畜(禽)营养代谢及中毒病与环境监测饲料功能性添加剂研发。现为中国家畜内科学研究会常务理事、中国动物毒物学会理事、亚洲家畜内科学研究会发起人之一(理事)、江西奶业协会常务理事、江西动物保健品协会理事。江西省动物卫生和动物产品安全风险评估专家组专家,江西动物重大疫病专家组专家。先后主持完成国家自然科学基金项目6项,国家“十四五”“十三五”重点研发项目3项以及省、厅级等科研项目30余项。获江西省科技进步贰等奖1项,江西省科技进步叁等奖3项,江西省高校科技成果壹等奖1项,江西省高校科技成果叁等奖1项、江西省农科教突出贡献奖叁等奖1项,王止川科学奖励基金优秀畜牧兽医科技成果壹等奖1项和叁等奖1项。主编或参编兽医高等教育规划教材6部;先后发表学术论文200余篇,其中SCI收录100余篇,A类学报20余篇。
长期担任研究生和本科生《兽医临床诊断学》、《家畜内科学》、《畜禽营养代谢病》、《畜禽中毒病》、《兽医临床诊断学实验技术》、《专业外语》、《临床兽医学实践》等课程的教学。参编全国高等农业院校教学指导委员会审定教材《兽医临床诊断学》、《小动物内科学》、《动物临床病理学》、《兽医临床诊疗学》等教材;五年来发表教学改革论文4篇;参与本科生教学改革项目3项,其中《牛的肌肉及内脏虚拟仿真解剖实验系统》获首批国家级一流本科课程。兽医专业获国家级首批特色专业建设点,入选卓越农林人才教育培养计划项目及江西省一流专业建设项目,2个基地得到教育部专项建设。近10年来,承担国家级质量工程项目4项,公司产品改革项目19项,精品课程建设8门,教学改革论文30篇,出版国家统编教材或专著20余部,取得一系列公司产品研究成果。
近年主持的科研项目:
[1] 国家重点研发计划项目:畜禽普通病监测及群体保健技术研发与应用-子课题(2023YFD1801100),2023.12-2026.12,30万;
[2] 国家自然科学基金项目(面上项目):MiR-15b-5p通过靶向SIRT3调节线粒体能量代谢在蛋鸡脂肪肝出血综合征中的调控机制(32373090),2024.1-2027.12,50万;
[3] 国家自然科学基金项目(地区项目):肠道菌群及代谢产物短链脂肪酸对FLHS蛋鸡胰岛素抵抗的作用及调控机制(32060819),2022.1-2025.12,35万;
[4] 国家重点研发计划项目:高产蛋鸡高效安全养殖技术应用与示范-子课题(2018YFD0501302),2016.1-2020.12,55万;
[5] 国家重点研发计划项目:禽碳水化合物、蛋白质与能量代谢失衡防控技术研究-子课题(2016YFD0501205),2016.1-2020.12,67.5万;
[6] 国家自然科学基金项目(地区项目):Insulin/PI3K/Akt信号通路对高能低蛋白日粮致蛋鸡脂肪肝出血综合征形成机制研究(31560715),2016.1-2019.12,48万;
[7] 国家自然科学基金项目(地区项目):不同鸡品种(系)与个体apoA-I基因型及表达量与FLHS关系研究(31160522),2012.1-2015.12,55万;
[8]国家自然科学基金项目(地区项目):蛋鸡脂肪肝综合征(FLHS)中apoA-Ⅰ和apoB-100基因表达变化研究(30760180),2008.1-2010.12,17万;
[9] 国家自然科学基金项目(地区项目):蛋鸡脂肪肝综合征中血浆载脂蛋白A及其亚类的研究(30160064),2008.1-2010.12,18万;
[10] 江西省主要学科学术和技术带头人资助计划项目:apoA-Ⅰ、apoB-100基因在蛋鸡脂肪肝出血性综合征(FLHS)中生物功能分析及调控机制研究,2017.3-2019.6,50万;
[11] 江西省“千人计划”科技创新高端人才项目(jxsq2023201060),2023.3,200万;
[12] 江西省自然基金项目:鸡FLHS与血浆脂类代谢及apoAⅠ基因多态性关系的研究(2007GZN0263),2008.1-2010.12,2万;
[13] 江西省科技计划项目:基于对载脂蛋白A基因调控以降低鸡(蛋)产品中有害胆固醇、提高有益胆固醇的研究与开发(20111BBF60019),2012.1-2014.12,5万。
近年获得的奖励:
[1] 江西省普通高校金牌教师“金牌研究生导师”,2022。
[2] 伟德国际BETVlCTOR教学成果一等奖:“课程筑本、载体赋能、劳创融合”三层递进式动物医学专业育人新模式的构建与实践,证书号:202212032,2022,排名第二;
[3] 伟德国际BETVlCTOR研究生教学成果奖二等奖:思政引领,科技添翼,服务铸魂——创新兽医学系列课程建设的探索与实践,证书号:JXAU20220010,2022,排名第一;
[4] 江西省教学成果二等奖:兽医学科“四位一体”建设助推高层次兽医人才培养模式的构建与实施,证书号:20212131,2021,排名第一;
[5] 伟德国际BETVlCTOR研究生教学成果一等奖:兽医学科“四位一体”构建助推高层次兽医人才培养模式的构建与实践,证书号:JXAU20200005,2020,排名第一;
[6] 伟德国际BETVlCTOR研究生教学成果一等奖,“五位一体”兽医团队建设助推高层次兽医人才的培养,证书号:JXAU20190003,2019,排名第一;
[7] 江西省自然科学三等奖:蛋鸡脂肪肝出血综合征发病机制及其防控研究,证书号:Z-12-3-05-R02,2012,排名第一;
[8] 江西省高等学校科技成果三等奖:甜菜碱对蛋鸡脂类代谢影响的研究,证书号:J1103043,2011,排名第一;
[9] 江西省高等学校科技成果三等奖:不同铜源对肉鸡肝脏及其线粒体功能的影响,证书号:J1103040,2011,排名第二;
[10] 江西省高等学校科技成果三等奖:蛋鸡脂肪肝出血综合征发病机理研究,证书号:J090334,2009,排名第一;
[11] 江西省高等学校科技成果三等奖:高钙日粮致鸡痛风的机理研究,证书号:J090332,2009,排名第二;
[12] 江西省农科教突出贡献奖三等奖:推广兽医新技术研究,证书号:99-3-129,1999,排名第一。
近三年发表论文(部分):
[1] Xinyi Cheng, Yang Hu, Xiaoqing Yu, Jinyan Chen, Xiaoquan Guo, Huabin Cao, Guoliang Hu*, Yu Zhuang*. Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway. Antioxidants (Basel). 2024 Jan 23;13(2):140. (SCI, IF: 7.0, 中科院二区,通讯作者);
[2] Jiahua Liang, Jinyan Chen, Lingling Yang, Dan Wu, Lijuan Xiong, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Guoliang Hu*, Yu, Zhuang*. Curcumin alleviates atrazine-induced cardiotoxicity by inhibiting endoplasmic reticulum stress-mediated apoptosis in mice through ATF6/Chop/Bcl-2 signaling pathway. Biomedicine & Pharmacotherapy, 2024;171:116205. (SCI, IF: 7.5, 中科院二区,通讯作者);
[3] Xinyi Cheng, Jinyan Chen, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Guoliang, Hu*, Yu Zhuang*. Disrupting the gut microbiota/metabolites axis by Di-(2-ethylhexyl) phthalate drives intestinal inflammation via AhR/NF-κB pathway in mice. Environmental pollution,2024;343:123232. (SCI, IF: 8.9, 中科院二区,通讯作者);
[4] Chang Wang, Yitian Yang, Jinyan Chen, Xueyan Dai, Chenghong Xing, Caiying Zhang, Huabin Cao, Xiaoquan Guo, Guoliang Hu*, Yu Zhuang*. Berberine Protects against High-Energy and Low-Protein Diet-Induced Hepatic Steatosis: Modulation of Gut Microbiota and Bile Acid Metabolism in Laying Hens. International journal of molecular,2023;24(24):17304. (SCI, IF: 5.6, 中科院二区,通讯作者);
[5] Chang Wang, Xueyan Dai, Chenghong Xing, Caiying Zhang, Huabin Cao, Xiaoquan Guo, Ping Liu, Fan Yang, Yu Zhuang*, Guoliang Hu*. Hexavalent-Chromium-Induced Disruption of Mitochondrial Dynamics and Apoptosis in the Liver via the AMPK-PGC-1α Pathway in Ducks. International journal of molecular,2023;24(24):17241. (SCI, IF: 5.6, 中科院二区,通讯作者);
[6] Jiahua Liang, Ying Zhou, Xinyi Cheng, Jiaqi Chen, Huabin Cao, Xiaoquan Guo, Caiying Zhang, Yu Zhuang*, Guoliang Hu*. Baicalin Attenuates H2O2-Induced Oxidative Stress by Regulating the AMPK/Nrf2 Signaling Pathway in IPEC-J2 Cells. International journal of molecular,2023;24(11):9435. (SCI, IF: 5.6, 中科院二区,通讯作者);
[7] Xinyi Cheng, Jiahua Liang, Dan Wu, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Ping Liu, Ruiming Hu, Guoliang Hu*, Yu Zhuang*. Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux. Ecotoxicology and Environmental Safety,2023;257:114942. (SCI, IF: 6.8, 中科院二区,通讯作者);
[8] Zhanyou Cao, Chenghong Xing, Xinyi Cheng, Junrong Luo, Ruiming Hu, Huabin Cao, Xiaoquan Guo, Fan Yang, Yu Zhuang*, Guoliang Hu*. Luteolin Attenuates APEC-Induced Oxidative Stress and Inflammation via Inhibiting the HMGB1/TLR4/NF-κB Signal Axis in the Ileum of Chicks. Animals (Basel), 2022;13(1):83.(SCI, IF: 3.0, 中科院二区,通讯作者);
[9] Zhanyou Cao, Fan Yan, Yiqun Lin, Jiyi Shan, Huabin Cao, Caiying Zhang, Yu Zhuang, Chenghong Xing, Guoliang Hu*. Selenium Antagonizes Cadmium-Induced Inflammation and Oxidative Stress via Suppressing the Interplay between NLRP3 Inflammasome and HMGB1/NF-κB Pathway in Duck Hepatocytes. International journal of molecular sciences, 2022;23(11):6252. (SCI, IF: 5.6, 中科院二区,通讯作者);
[10] Xinyi Cheng, Jiuyue Liu, Yibo Zhu, Xiaoquan Guo, Ping Liu, Caiying Zhang, Huabin Cao, Chenghong Xing, Yu Zhuang*, Guoliang Hu*. Molecular cloning, characterization, and expression analysis of TIPE1 in chicken (Gallus gallus): Its applications in fatty liver hemorrhagic syndrome. International journal of molecular sciences, 2022;207:905-916.(SCI, IF: 5.6, 中科院二区,通讯作者);
[11] Caiying Zhang, Tianjin Lin, Gaohui Nie, Ruiming Hu, Shaoxing Pi, Zejing Wei, Chang Wang, Guyue Li, Guoliang Hu*. In vivo assessment of molybdenum and cadmium co-induce nephrotoxicity via causing calcium homeostasis disorder and autophagy in ducks (Anas platyrhyncha). Ecotoxicology and environmental safety,2022;230:113099. (SCI, IF: 6.8, 中科院二区,通讯作者);
[12] Xinyi Cheng, Zhanyou Cao, Junrong Luo, Ruiming Hu, Huabin Cao, Xiaoquan Guo, Chenghong Xing, Fan Yang, Yu Zhuang, Guoliang Hu*. Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway. Poultry science, 2022;101(1):101572. (SCI, IF: 4.4, 中科院一区,通讯作者);
[13] Caiying Zhang, Xueru Wang, Gaohui Nie, Zejing Wei, Shaoxing Pi, Chang Wang, Fan Yang, Ruiming Hu, Chenghong Xing, Guoliang Hu*. In vivo assessment of molybdenum and cadmium co-induce nephrotoxicity via NLRP3/Caspase-1-mediated pyroptosis in ducks. Journal of inorganic biochemistry, 2021;224:111584. (SCI, IF: 3.9, 中科院二区, 通讯作者);
[14] Lujia Huang, Xiaoquan Guo, Pei Liu, Yulan, Zhao, Cong Wu, Changming Zhou, Cheng Huang, Guyue Li, Yu Zhuang, Sufang Cheng, Huabin Cao, Caiying Zhang, Zheng Xu, Xin Liu, Guoliang Hu*, Ping Liu*. Correlation between acute brain injury and brain metabonomics in dichlorvos-poisoned broilers. Journal of Hazardous Materials, 2022;422:126849. (SCI, IF:13.6, 中科院一区, 通讯作者);
[15] Jun Kuang, Puzhi Xu, Yan Shi, Yitian Yang, Ping Liu, Shupeng Chen, Changming Zhou, Guyue Li, Yu Zhuang, Ruiming Hu, Guoliang Hu*, Xiaoquan Guo*. Nephropathogenic Infectious Bronchitis Virus Infection Altered the Metabolome Profile and Immune Function of the Bursa of Fabricius in Chicken. Frontiers in Veterinary Science,2021;7:628270. (SCI, IF:3.2, 中科院二区, 通讯作者);
[16] Caiying Zhang, Tianjin Lin, Gaohui Nie, Ruiming Hu, Shaoxing Pi, Zejing Wei, Chang Wang, Chenghong Xing, Guoliang Hu*. Cadmium and molybdenum co-induce pyroptosis via ROS/PTEN/PI3K/AKT axis in duck renal tubular epithelial cells. Environmental pollution,2021;272:116403. (SCI, IF:8.9, 中科院二区, 通讯作者);
[17] Caiying Zhang, Xueru Wang, Shaoxing Pi, Zejing Wei, Chang Wang, Fan Yang, Guyue Li, Gaohui Nie*, Guoliang Hu*. Cadmium and molybdenum co-exposure triggers autophagy via CYP450s/ROS pathway in duck renal tubular epithelial cells. The Science of the total environment, 2021;759:143570. (SCI, IF: 9.8, 中科院一区, 通讯作者);
[18] Chenghong Xing, Wang Yun, Xueyan Dai, Fan Yang, Junrong Luo, Liu Ping, Caiying Zhang, Huabin Cao and Guoliang Hu*, The Protective Effects of Resveratrol On Antioxidant Function and the mRNA Expression of Inflammatory Cytokines in the Ovaries of Hens with Fatty Liver Hemorrhagic Syndrome, Poultry science, 2020 Feb, 99(2):1019-1027. (SCI, IF: 4.4, 中科院一区, 通讯作者);
[19] Xiaoyu Wang, Chenghong Xing, Fan Yang, Sihui Zhou, Guyue Li, Caiying Zhang, Huabin Cao and Guoliang Hu*. Abnormal Expression of Liver Autophagy and Apoptosis-Related mRNA in Fatty Liver Haemorrhagic Syndrome and Improvement Function of Resveratrol in Laying Hens, Avian Pathology, 2020 Apr, 49(2):171-78. (SCI, IF: 2.8, 中科院二区, 通讯作者);
[20] Chang Wang, Gaohui Nie, Fan Yang, Jian Chen, Yu Zhuang, Xueyan Dai, Zhiyue Liao, Zhi Yang, Huabin Cao, Chenghong Xing,Guoliang Hu* and Caiying Zhang*. Molybdenum and Cadmium Co-Induce Oxidative Stress and Apoptosis through Mitochondria-Mediated Pathway in Duck Renal Tubular Epithelial Cells, Journal of Hazardous Materials, 2020 Feb, 383:121157. (SCI, IF:13.6, 中科院一区,通讯作者);
[21] Jionghan Zhuang, Gaohui Nie, Fan Yang, Huabin Cao, Chenghong Xing, Xueyan Dai, Guoliang Hu* and Caiying Zhang*. Molybdenum and Cadmium Co-Induced the Levels of Autophagy-Related Genes Via Adenosine 5'-Monophosphate-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling Pathway in Shaoxing Duck (Anas Platyrhyncha) Kidney, Poultry science, 2019 Dec, 98(12):6533-41. (SCI, IF: 4, 中科院一区, 通讯作者);
[22] Jionghan Zhuang, Gaohui Nie, Fan Yang, Xueyan Dai, Huabin Cao, Chenghong Xing, Guoliang Hu* and Caiying Zhang*. Cadmium Induces Cytotoxicity through Oxidative Stress-Mediated Apoptosis Pathway in Duck Renal Tubular Epithelial Cells, Toxicology in Vitro, 2019 Dec, 61:104625. (SCI, IF: 3.2, 中科院二区,通讯作者);
[23] Yu Zhuang, Chenghong Xing, Huabin Cao, Caiying Zhang, Junrong Luo, Xiaoquan Guo and Guoliang Hu*. Insulin Resistance and Metabonomics Analysis of Fatty Liver Haemorrhagic Syndrome in Laying Hens Induced by a High-Energy Low-Protein Diet, Scientific Reports, 2019 Jul, 9(1):10141. (SCI, IF: 4.6, 中科院二区, 通讯作者);
[24] Xueyan Dai, Gaohui Nie, Huabin Cao, Chenghong Xing, Guoliang Hu* and Caiying Zhan*. In Vivo Assessment of Molybdenum and Cadmium Co-Induced the mRNA Levels of Heat Shock Proteins, Inflammatory Cytokines and Apoptosis in Shaoxing Duck (Anas Platyrhyncha) Testicles. Poultry science, 2019 Nov, 98(11):5424-31. (SCI, IF:4.4, 中科院一区, 通讯作者);
[25] Yezhao Ruan, Cong Wu, Xiaoquan Guo, Zheng Xu, Chenghong Xing, Huabin Cao, Caiying Zhang, Guoliang Hu* and Ping Liu*. High Doses of Copper and Mercury Changed Cecal Microbiota in Female Mice, Biological Trace Element Research, 2019 May, 189(1):134-44. (SCI, IF:3.9, 中科院三区, 通讯作者)。
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